Detailed Error Information:
Module IIS Web Core
Notification BeginRequest
Handler Not yet determined
Error Code 0x80070021
Config Error This configuration section cannot be used at this path. This happens when the section is locked at a parent level. Locking is either by default (overrideModeDefault="Deny"), or set explicitly by a location tag with overrideMode="Deny" or the legacy allowOverride="false".
Config File \\?\C:\CMC\WebSites\CMCAbleDev\web.config
Requested URL https://cmc-able-dev.cmc.ca:443/
Physical Path C:\CMC\WebSites\CMCAbleDev
Logon Method Not yet determined
Logon User Not yet determined

Hi
I modified the locking to allow, now I get:

HTTP Error 500.21 - Internal Server Error
Handler "ExtensionlessUrlHandler-Integrated-4.0" has a bad module "ManagedPipelineHandler" in its module list

Most likely causes:
Managed handler is used; however, ASP.NET is not installed or is not installed completely.
There is a typographical error in the configuration for the handler module list.
During application initialization, either the application initialization feature has set skipManagedModules to true, or a rewrite rule is setting a URL that maps to a managed handler and is also setting SKIP_MANAGED_MODULES=1.

Things you can try:
Install ASP.NET if you are using managed handler.
Ensure that the handler module's name is specified correctly. Module names are case-sensitive and use the format modules="StaticFileModule,DefaultDocumentModule,DirectoryListingModule".
Ensure that any application initialization rewrite rules set SKIP_MANAGED_MODULE=0 when setting a URL that maps to a managed handler (such as .aspx, for example.)
As an alternative, ensure that application initialization rewrite rules map the request to an unmanaged handler (for example, to an .htm file, which is mapped to the StaticFileHandler.)